There’s no shortage of weight-loss supplements on the market claiming to make dieting a snap.
The problem is, supplement companies have a tendency to overstate—and occasionally downright lie about—how effective their supplements for weight loss are.
The truth is, there are many weight-loss supplements that actually work, but these are the exception, rather than the rule.
In this article you’ll learn the seven best supplements for weight loss, and three common weight-loss supplements you should definitely avoid.
You’ll also learn more about the best weight loss supplement for men and women, PCOS weight-loss supplements, weight loss supplements for menopause, and more.
Table of Contents
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What is it?: Caffeine is a natural central nervous system (CNS) stimulant and is the most widely taken psychoactive drug in the world.
Caffeine is most commonly sourced from coffee beans, but can also be found naturally in certain types of tea and cacao beans.
If you use caffeine regularly, however, this increase in metabolic rate lessens in intensity (you become tolerant to caffeine’s effects), which is why it’s not advisable to use caffeine continuously for multiple weeks if you want to use it as a supplement for weight-loss.
To maximize caffeine’s weight-loss benefits, use up to 500 milligrams once a week on your most difficult workout days, or 100-to-200 milligrams per day for one-to-two weeks at a time before stopping caffeine usage for an equal amount of time.
Is it safe?: Caffeine consumption is generally considered to be safe.
That said, if you consume too much caffeine you may experience side effects such as insomnia, upset stomach, fluctuating energy levels, heart palpitations or increased heart rate, anxiety, tremors, and headaches.
What is it?: Yohimbine is a naturally occurring substance that’s found in several types of plants native to central and western Africa, including the bark of the yohimbe tree.
How does it work?: The details of how yohimbine speeds up fat loss are rather technical, but the gist is it “deactivates” a mechanism in fat cells that prevents them from being burned.
In a sense, yohimbine helps “take the brakes off” of fat loss so your body’s natural fat-burning chemicals can work more effectively.
Is it safe?: When taken in higher doses, yohimbine may contribute to anxiety or impulsivity. Thus, yohimbine is not recommended for people with anxiety or panic disorders.
For the rest of us, though, research shows that moderate doses of yohimbine are generally well tolerated.
What is it?: Thai ginseng, also known as Kaempferia parviflora, is an herb native to Thailand that has traditionally been used to improve virility and physical performance and support weight management.
How does it work?: Thai ginseng works as a natural weight-loss supplement because it contains several active compounds known as methoxyflavones which . . .
- Increase energy expenditure by causing an effect in fat cells known as uncoupling
- Decrease fat storage by influencing a receptor known as PPARy
Is it safe?: One review study of Thai ginseng found you can use up to 1.35 grams per day without experiencing any adverse effects. This is significantly higher than the clinically effective dose of between 90 and 180 milligrams per day found in most safe weight-loss supplements.
What is it?: Grains of Paradise is the common name for the plant Aframomum melegueta, which is a herb in the ginger family that’s commonly used as a spice.
How does it work?: It contains various compounds like 6-gingerol and 6-paradol that can increase the metabolic rate by influencing receptors on fat cells involved in energy regulation and perception of temperature.
Is it safe?: Research shows that Grains of Paradise is safe to use as a healthy weight-loss supplement unless you take doses that far exceed the clinically effective dose of around 30 milligrams.
What is it?: Forskolin is a substance found in the Indian herb Coleus forskohlii, which has long been used in Ayurvedic medicine to treat heart and respiratory disorders.
How does it work?: Supplementation with forskolin increases blood plasma and intracellular levels of a molecule known as cAMP (cyclic adenosine monophosphate), which stimulates the production of cellular energy.
This is why research shows that supplementation with forskolin accelerates fat loss and appears to increase testosterone levels as well.
Is it safe?: Most studies show that forskolin is very safe to take. That said, in some rare cases people supplementing with forskolin have reported experiencing side effects such as diarrhea, nausea and vomiting, constipation, headache, and fatigue.
What is it?: Fucoxanthin is a vitamin A-like molecule known as a carotenoid that’s found in seaweed (and that gives brown seaweed it’s color)
(Funny side note: it was once thought that fucoxanthin could convert white fat into brown fat but researchers had simply forgotten that fucoxanthin was just a brown pigment making it look different.)
What is it?: 5-HTP is a compound produced by the metabolism of the amino acid tryptophan, which is found in foods like milk, meat, potatoes, pumpkin, and various greens.
It’s converted into serotonin in the brain, which is one of the principal neurotransmitters involved in feelings of happiness.
How does it work?: When you diet to lose weight, your body produces hormones that make you feel hungry.
5-HTP makes this list of top weight-loss supplements because it helps to nullify these hormones, which increases feelings of fullness, helps control food intake, and curbs cravings for carbohydrates, all of which help you lose weight.
Is it safe?: 5-HTP is safe to take for most people, though if you take very large doses (600 milligrams per day or more) some may experience side effects including nausea, insomnia, diarrhea, stomach pain, and amenorrhea.
It’s also recommended that you steer clear of 5-HTP if you are taking medication that increases serotonin levels (such as antidepressants or prescription painkillers) as this can make the serotonin levels in your body dangerously high.
You don't need supplements to build muscle, lose fat, and get healthy. But the right ones can help. Take this quiz to learn which ones are best for you.
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You don't need supplements to build muscle, lose fat, and get healthy. But the right ones can help. Take this quiz to learn which ones are best for you.Take the Quiz
Hoodia is a cactus-like plant that grows in Africa’s Kalahari Desert. Historically, the San Bushmen ate hoodia when food and water were scarce to mitigate thirst and hunger pangs.
Hoodia gordonii is a top three fat loss failure since it actively harms you and, despite that, doesn’t even have the common courtesy to help you lose fat.
Conjugated linoleic acid (CLA) is a fatty acid found in meat and dairy.
Research shows that CLA may . . .
- Help you lose body fat
- Only be as effective as placebo at helping you lose body fat
- Make you gain body fat
And that’s why it makes it to our top three worst supplements for weight loss. It’s unreliable and inconsistent in its effects (and most data shows it’s a dud).
Garcinia cambogia is a small yellow fruit that’s widely used in natural weight-loss supplements.
The reason it’s on this rogue’s gallery of supplements for weight loss is there isn’t enough convincing evidence that it helps you lose weight (and that’s kind of a prerequisite for being included in the best weight-loss supplements section).
Don’t waste your money gambling on something that may or may not help you reach your weight-loss goals—stick to one of the top weight-loss supplements listed above instead.
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Many supplement companies sell weight-loss supplements that they claim are designed specifically for the female body.
This, however, is utter bunk.
The underlying mechanism of fat loss is the same for men and women, which means the supplements that speed up the process are the same whether you’re male or female.
As such, the supplements discussed in this article are the best weight-loss supplements for women (and the best weight-loss supplements for men, too).
If you’re looking for a medically-proven weight-loss supplement that combines clinically effective doses of many of the ingredients above, then check out Legion’s 100% natural fat burner, Phoenix.
(Or if you aren’t sure if Phoenix is right for you or if another supplement might be a better fit for your budget, circumstances, and goals, then take the Legion Supplement Finder Quiz! In less than a minute, it’ll tell you exactly what supplements are right for you. Click here to check it out.)
Many supplement companies sell weight-loss supplements that they claim are designed specifically for the male body.
This, however, is complete tosh.
The underlying mechanism of fat loss is the same for men and women, which means the supplements that rev the process in men are the same as those that speed up fat loss in women.
As such, the supplements discussed in this article are the best weight-loss supplements for men (and the best weight-loss supplements for women, too).
Polycystic ovary syndrome (PCOS) is a condition that causes a woman’s ovaries or adrenal glands to produce higher-than-normal amounts of male hormones. It also causes cysts to grow on the ovaries.
This leads many women with PCOS to seek out quick weight-loss supplements that will help them get their condition under control.
Unfortunately, no amount of weight loss pills and powders are going to magically improve the symptoms of PCOS. The good news, however, is that if you know how to eat and train to drive fat loss, certain supplements can help.
Aside from the supplements already discussed in this article, some supplements that may help women with PCOS lose weight are:
- Inositol: Inositol, also known as myo-inositol, is a carbocyclic sugar that is found in tissues throughout the body. Several studies show that inositol is effective at improving insulin sensitivity and lowering blood pressure in women with PCOS, which may aid weight loss.
- Omega-3 Fatty Acids: Omega-3 fatty acids are a type of fat found in foods such as fish and flaxseed, and in dietary supplements such as fish oil. Research shows that omega-3 fatty acids may help to improve insulin sensitivity in women with PCOS which should make losing weight easier.
(And if you’d like to try a high-potency, molecularly distilled fish oil with added vitamin E and lemon oil to prevent oxidation, rancidity, and “fish oil burps,” try Legion’s fish oil supplement, Triton.)
- Protein powder: Studies show that women with PCOS who eat a high-protein diet are better able to manage their weight than those who eat a low-protein diet. While you should get most of your daily protein from nutritious foods, protein powder is a convenient and practical way to boost your protein intake that may help you lose weight as part of a calorie-controlled diet.
(And if you want a clean, all-natural, delicious tasting whey protein isolate that’s naturally sweetened and flavored and free of chemicals, GMOs, and hormones, then you want WHEY+.)
Finally, if you’d like specific advice about what diet to follow to reach your fitness goals, take the Legion Diet Quiz.
It’s common for women to gain weight around the time of the menopause.
Sadly, no supplement can make you lose weight during or after menopause on its own. To lose weight and maintain your health during menopause—or any stage of life for that matter—the best things to do are:
- Use an aggressive (but not reckless) calorie deficit of 20-to-25%.
- Eat a high-protein diet.
- Do resistance training.
Assuming you have these in place, though, taking proven weight-loss supplements can help speed up the fat loss process.
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I wouldn’t recommend it.
There’s very little research on whether it’s safe to take weight-loss supplements while breastfeeding. Thus, as a precaution, it’s best to avoid them until you’ve finished nursing.
+ Scientific References
- Evans, J., Richards, J. R., & Battisti, A. S. (2021). Caffeine. Principles of Nutrigenetics and Nutrigenomics: Fundamentals of Individualized Nutrition, 335–340. https://www.ncbi.nlm.nih.gov/books/NBK519490/
- TE, G., & LL, S. (1995). Metabolic, catecholamine, and exercise performance responses to various doses of caffeine. Journal of Applied Physiology (Bethesda, Md. : 1985), 78(3), 867–874. https://doi.org/10.1152/JAPPL.19188.8.131.527
- KJ, A., B, Z.-M., P, P., K, A., & E, J. (1980). Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals. The American Journal of Clinical Nutrition, 33(5), 989–997. https://doi.org/10.1093/AJCN/33.5.989
- J, B., K, J., N, N., NJ, C., & T, G. (1992). Acute and habitual caffeine ingestion and metabolic responses to steady-state exercise. Journal of Applied Physiology (Bethesda, Md. : 1985), 72(4), 1297–1303. https://doi.org/10.1152/JAPPL.19184.108.40.2067
- Robertson, D., Wade, D., Workman, R., Woosley, R. L., & Oates, J. A. (1981). Tolerance to the humoral and hemodynamic effects of caffeine in man. Journal of Clinical Investigation, 67(4), 1111. https://doi.org/10.1172/JCI110124
- A Astrup, L Breum, S Toubro, P Hein, & F Quaade. (n.d.). The effect and safety of an ephedrine/caffeine compound compared to ephedrine, caffeine and placebo in obese subjects on an energy restricted diet. A double blind trial - PubMed. Retrieved November 4, 2021, from https://pubmed.ncbi.nlm.nih.gov/1318281/
- WJ, P., MS, W.-P., & WH, S. (1997). The effectiveness of long-term supplementation of carbohydrate, chromium, fibre and caffeine on weight maintenance. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, 21(12), 1143–1151. https://doi.org/10.1038/SJ.IJO.0800528
- Temple, J. L., Bernard, C., Lipshultz, S. E., Czachor, J. D., Westphal, J. A., & Mestre, M. A. (2017). The Safety of Ingested Caffeine: A Comprehensive Review. Frontiers in Psychiatry, 8, 80. https://doi.org/10.3389/FPSYT.2017.00080
- Reissig, C. J., Strain, E. C., & Griffiths, R. R. (2009). Caffeinated Energy Drinks -- A Growing Problem. Drug and Alcohol Dependence, 99(1–3), 1. https://doi.org/10.1016/J.DRUGALCDEP.2008.08.001
- PA, C., YH, W., G, M., R, D., & IA, K. (2016). Pharmaceutical quantities of yohimbine found in dietary supplements in the USA. Drug Testing and Analysis, 8(3–4), 357–369. https://doi.org/10.1002/DTA.1849
- M, L., M, B., J, G., & JL, M. (1992). Alpha-2 adrenoceptors in lipolysis: alpha 2 antagonists and lipid-mobilizing strategies. The American Journal of Clinical Nutrition, 55(1 Suppl). https://doi.org/10.1093/AJCN/55.1.219S
- F, C. (2009). Anxiolytics antagonize yohimbine-induced central noradrenergic activity: a concomitant in vivo voltammetry-electrophysiology model of anxiety. Journal of Neuroscience Methods, 180(1), 97–105. https://doi.org/10.1016/J.JNEUMETH.2009.03.007
- J, G., M, T., M, B., D, R., M, G., & M, L. (1988). Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers. European Journal of Clinical Investigation, 18(6), 587–594. https://doi.org/10.1111/J.1365-2362.1988.TB01272.X
- SM, O. (2006). Yohimbine: the effects on body composition and exercise performance in soccer players. Research in Sports Medicine (Print), 14(4), 289–299. https://doi.org/10.1080/15438620600987106
- AC, S., M, L., SD, L., B, C., JL, S., & FG, M. (2013). Norepinephrine and impulsivity: effects of acute yohimbine. Psychopharmacology, 229(1), 83–94. https://doi.org/10.1007/S00213-013-3088-7
- M, S., M, B., T, A., J, B., A, K., K, J., D, E., U, B., F, H., & A, B. (2011). Psychological and neuroendocrine responses to social stress and to the administration of the alpha-2-receptor antagonist, yohimbine, in highly trained endurance athletes in comparison to untrained healthy controls. Pharmacopsychiatry, 44(4), 129–134. https://doi.org/10.1055/S-0031-1277166
- MF, M. (2002). Pre-exercise administration of yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis. Medical Hypotheses, 58(6), 491–495. https://doi.org/10.1054/MEHY.2001.1459
- M, M., T, Y., S, A., T, K., N, K., K, Y., K, T., T, K., H, S., & M, S. (2015). Kaempferia parviflora extract increases whole-body energy expenditure in humans: roles of brown adipose tissue. Journal of Nutritional Science and Vitaminology, 61(1), 79–83. https://doi.org/10.3177/JNSV.61.79
- S, Y., M, K., R, A., H, K., Y, K., & T, K. (2014). Kaempferia parviflora extract increases energy consumption through activation of BAT in mice. Food Science & Nutrition, 2(6), 634–637. https://doi.org/10.1002/FSN3.144
- Y, O., T, S., T, H., K, K., K, K., K, I., M, A., & K, T. (2014). Suppression of adipocyte hypertrophy by polymethoxyflavonoids isolated from Kaempferia parviflora. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 21(6), 800–806. https://doi.org/10.1016/J.PHYMED.2014.01.014
- Saokaew, S., Wilairat, P., Raktanyakan, P., Dilokthornsakul, P., Dhippayom, T., Kongkaew, C., Sruamsiri, R., Chuthaputti, A., & Chaiyakunapruk, N. (2017). Clinical Effects of Krachaidum (Kaempferia parviflora): A Systematic Review. Journal of Evidence-Based Complementary & Alternative Medicine, 22(3), 413. https://doi.org/10.1177/2156587216669628
- J, S., T, Y., Y, S., T, I., H, U., I, S., & M, S. (2014). Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans. Journal of Nutritional Science and Vitaminology, 60(1), 22–27. https://doi.org/10.3177/JNSV.60.22
- J, S., T, Y., T, H., S, A., T, I., H, U., T, I., T, K., Y, K., & M, S. (2013). Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men. The British Journal of Nutrition, 110(4), 733–738. https://doi.org/10.1017/S0007114512005715
- Ilic, N., Schmidt, B. M., Poulev, A., & Raskin, I. (2010). Toxicological evaluation of Grains of Paradise (Aframomum melegueta) [Roscoe] K. Schum. Journal of Ethnopharmacology, 127(2), 352–356. https://doi.org/10.1016/J.JEP.2009.10.031
- I Litosch, T H Hudson, I Mills, S Y Li, & J N Fain. (n.d.). Forskolin as an activator of cyclic AMP accumulation and lipolysis in rat adipocytes - PubMed. Retrieved November 4, 2021, from https://pubmed.ncbi.nlm.nih.gov/6289066/
- C, P., D, P., M, H., TC, M., GH, L., & R, S. (2008). Activation and inhibition of adenylyl cyclase isoforms by forskolin analogs. The Journal of Pharmacology and Experimental Therapeutics, 325(1), 27–36. https://doi.org/10.1124/JPET.107.131904
- MP, G., BA, J., & SR, R. (2005). Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obesity Research, 13(8), 1335–1343. https://doi.org/10.1038/OBY.2005.162
- Nishijima, C., Chiba, T., Sato, Y., & Umegaki, K. (2019). Nationwide Online Survey Enables the Reevaluation of the Safety of Coleus forskohlii Extract Intake Based on the Adverse Event Frequencies. Nutrients, 11(4). https://doi.org/10.3390/NU11040866
- H, M., M, H., T, S., K, F., & K, M. (2005). Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochemical and Biophysical Research Communications, 332(2), 392–397. https://doi.org/10.1016/J.BBRC.2005.05.002
- M, A., Z, R., R, S., & S, G. (2010). The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat. Diabetes, Obesity & Metabolism, 12(1), 72–81. https://doi.org/10.1111/J.1463-1326.2009.01132.X
- SI, K., HC, K., HS, S., HM, K., YS, H., NH, L., & SJ, K. (2011). Fucoxanthin exerts differing effects on 3T3-L1 cells according to differentiation stage and inhibits glucose uptake in mature adipocytes. Biochemical and Biophysical Research Communications, 409(4), 769–774. https://doi.org/10.1016/J.BBRC.2011.05.086
- H, M., M, H., T, S., K, M.-F., & K, M. (2009). Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model. Molecular Medicine Reports, 2(6), 897–902. https://doi.org/10.3892/MMR_00000189
- Riccioni, G., D’Orazio, N., Franceschelli, S., & Speranza, L. (2011). Marine Carotenoids and Cardiovascular Risk Markers. Marine Drugs, 9(7), 1166. https://doi.org/10.3390/MD9071166
- MC, Z., D, L., M, P. S., M, P., J, P., P, P.-P., F, M., P, S., C, G., Y, L., P, B., C, I., I, R., M, B., & MT, M. (2008). Toxicity and antioxidant activity in vitro and in vivo of two Fucus vesiculosus extracts. Journal of Agricultural and Food Chemistry, 56(17), 7773–7780. https://doi.org/10.1021/JF8007053
- C, I., S, T., T, K., S, S., M, T., T, O., T, N., T, T., JN, U., N, T., K, O., T, Y., T, O., & N, M. (2008). Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol. International Journal of Cancer, 123(11), 2702–2712. https://doi.org/10.1002/IJC.23860
- HJ, L., KA, D., BR, F., KM, D., & NI, W. (2007). Twenty-four-hour ghrelin is elevated after calorie restriction and exercise training in non-obese women. Obesity (Silver Spring, Md.), 15(2), 446–455. https://doi.org/10.1038/OBY.2007.542
- LK, H., EE, J., GM, S., L, Z., E, B., Z, T.-J., HY, L., JM, Z., N, B., T, K., CE, L., CJ, A., CY, Z., J, Y., O, B., KG, M., PG, C., BB, L., JM, F., … MA, C. (2006). Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron, 51(2), 239–249. https://doi.org/10.1016/J.NEURON.2006.06.004
- C, C., A, L., M, D. Ben, I, P., F, A., A, C., & F, R.-F. (1998). Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, 22(7), 648–654. https://doi.org/10.1038/SJ.IJO.0800642
- C, C., F, C., M, C., A, C., M, D. Ben, A, L., M, M., & F, R.-F. (1991). Effects of 5-hydroxytryptophan on eating behavior and adherence to dietary prescriptions in obese adult subjects. Advances in Experimental Medicine and Biology, 294, 591–593. https://doi.org/10.1007/978-1-4684-5952-4_73
- C, C., F, C., A, C., M, D. Ben, A, L., M, M., F, A., & F, R.-F. (1992). Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. The American Journal of Clinical Nutrition, 56(5), 863–867. https://doi.org/10.1093/AJCN/56.5.863
- F, C., C, C., M, C., A, C., M, D. Ben, M, M., L, S., & F, R. F. (1989). The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects. Journal of Neural Transmission, 76(2), 109–117. https://doi.org/10.1007/BF01578751
- M, R., A, O., M, F., M, B., & S, P. (2012). Relationship between the absorption of 5-hydroxytryptophan from an integrated diet, by means of Griffonia simplicifolia extract, and the effect on satiety in overweight females after oral spray administration. Eating and Weight Disorders : EWD, 17(1). https://doi.org/10.3275/8165
- RJ, W., & JJ, W. (1995). Brain serotonin, carbohydrate-craving, obesity and depression. Obesity Research, 3 Suppl 4. https://doi.org/10.1002/J.1550-8528.1995.TB00215.X
- F, T., A, D., J, A., & A, C. (1986). 5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial. European Neurology, 25(5), 327–329. https://doi.org/10.1159/000116030
- Volpi-Abadie, J., Kaye, A. M., & Kaye, A. D. (2013). Serotonin Syndrome. The Ochsner Journal, 13(4), 533. /pmc/articles/PMC3865832/
- Roza, O., Lovász, N., Zupkó, I., Hohmann, J., & Csupor, D. (2013). Sympathomimetic Activity of a Hoodia gordonii Product: A Possible Mechanism of Cardiovascular Side Effects. BioMed Research International, 2013. https://doi.org/10.1155/2013/171059
- I, V., JH, H., & AM, V. (2011). Hoodia gordonii: an up-to-date review of a commercially important anti-obesity plant. Planta Medica, 77(11), 1149–1160. https://doi.org/10.1055/S-0030-1250643
- WA, B., SL, A., R, B., GS, D., W, T., A, O., CL, W., & DJ, M. (2011). Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial. The American Journal of Clinical Nutrition, 94(5), 1171–1181. https://doi.org/10.3945/AJCN.111.020321
- Moya-Camarena, S. Y., Vanden Heuvel, J. P., & Belury, M. A. (1999). Conjugated linoleic acid activates peroxisome proliferator-activated receptor α and β subtypes but does not induce hepatic peroxisome proliferation in Sprague-Dawley rats. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1436(3), 331–342. https://doi.org/10.1016/S0005-2760(98)00121-0
- AC, W., AC, B., RN, C., Z, Z., & DA, S. (2007). The role of conjugated linoleic acid in reducing body fat and preventing holiday weight gain. International Journal of Obesity (2005), 31(3), 481–487. https://doi.org/10.1038/SJ.IJO.0803437
- SC, C., YH, L., HP, H., WL, H., JY, H., & CK, H. (2012). Effect of conjugated linoleic acid supplementation on weight loss and body fat composition in a Chinese population. Nutrition (Burbank, Los Angeles County, Calif.), 28(5), 559–565. https://doi.org/10.1016/J.NUT.2011.09.008
- SV, J., H, J., M, P., PL, M., RS, M., & PJ, J. (2011). Conjugated linoleic acid supplementation for 8 weeks does not affect body composition, lipid profile, or safety biomarkers in overweight, hyperlipidemic men. The Journal of Nutrition, 141(7), 1286–1291. https://doi.org/10.3945/JN.110.135087
- AA, S., F, T., CL, F., I, M., DM, J., G, H., MS, W., KW, W., B, A., & LM, W. (2008). Effect of a conjugated linoleic acid and omega-3 fatty acid mixture on body composition and adiponectin. Obesity (Silver Spring, Md.), 16(5), 1019–1024. https://doi.org/10.1038/OBY.2008.41
- U, R., B, V., J, A., & S, B. (2004). Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. The American Journal of Clinical Nutrition, 80(2), 279–283. https://doi.org/10.1093/AJCN/80.2.279
- LD, W., AC, W., & DA, S. (2007). Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. The American Journal of Clinical Nutrition, 85(5), 1203–1211. https://doi.org/10.1093/AJCN/85.5.1203
- AR, R., A, O., SM, D.-R., L, J., & A, R. (2017). Effect of Conjugated Linoleic Acid as a Supplement or Enrichment in Foods on Blood Glucose and Waist Circumference in Humans: A Metaanalysis. Endocrine, Metabolic & Immune Disorders Drug Targets, 17(1). https://doi.org/10.2174/1570161115999170207113803
- IJ, O., PP, P., LK, W., LA, D., & E, E. (2012). The efficacy of long-term conjugated linoleic acid (CLA) supplementation on body composition in overweight and obese individuals: a systematic review and meta-analysis of randomized clinical trials. European Journal of Nutrition, 51(2), 127–134. https://doi.org/10.1007/S00394-011-0253-9
- I, O., SK, H., R, P., B, W., & E, E. (2011). The Use of Garcinia Extract (Hydroxycitric Acid) as a Weight loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials. Journal of Obesity, 2011. https://doi.org/10.1155/2011/509038
- Chulaporn Roongpisuthipong, Rungthiwa Kantawan, & Wanjarus Roongpisuthipong. (n.d.). Reduction of adipose tissue and body weight: effect of water soluble calcium hydroxycitrate in Garcinia atroviridis on the short term treatment of obese women in Thailand - PubMed. Retrieved November 4, 2021, from https://pubmed.ncbi.nlm.nih.gov/17215177/
- K, H., Y, I., I, K., M, S., Y, O., N, S., H, T., M, F., G, Y., & H, S. (2003). Effects of garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial. Current Therapeutic Research, Clinical and Experimental, 64(8), 551–567. https://doi.org/10.1016/J.CURTHERES.2003.08.006
- SB, H., DB, A., JR, V., A, P., D, G., & C, N. (1998). Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA, 280(18), 1596–1600. https://doi.org/10.1001/JAMA.280.18.1596
- JE, K., SM, J., KH, P., WS, L., TS, J., RA, M., & MS, C. (2011). Does Glycine max leaves or Garcinia Cambogia promote weight-loss or lower plasma cholesterol in overweight individuals: a randomized control trial. Nutrition Journal, 10(1). https://doi.org/10.1186/1475-2891-10-94
- EM, K., MS, W.-P., & WH, S. (2001). The effects of 2-week ingestion of (--)-hydroxycitrate and (--)-hydroxycitrate combined with medium-chain triglycerides on satiety, fat oxidation, energy expenditure and body weight. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, 25(7), 1087–1094. https://doi.org/10.1038/SJ.IJO.0801605
- Tehrani, F. R., & Behboudi-Gandevani, S. (2015). Polycystic Ovary Syndrome. Contemporary Gynecologic Practice. https://doi.org/10.5772/59591
- Sam, S. (2007). Obesity and Polycystic Ovary Syndrome. Obesity Management, 3(2), 69. https://doi.org/10.1089/OBE.2007.0019
- Teede, H., Deeks, A., & Moran, L. (2010). Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Medicine, 8, 41. https://doi.org/10.1186/1741-7015-8-41
- JE, N., DJ, J., P, R., RD, G., & G, A. (1999). Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. The New England Journal of Medicine, 340(17), 1314–1320. https://doi.org/10.1056/NEJM199904293401703
- Nestler, J. E., Jakubowicz, D. J., Reamer, P., Gunn, R. D., & Allan, G. (2008). Ovulatory and Metabolic Effects of d-Chiro-Inositol in the Polycystic Ovary Syndrome. Http://Dx.Doi.Org/10.1056/NEJM199904293401703, 340(17), 1314–1320. https://doi.org/10.1056/NEJM199904293401703
- F, F., D, P., M, R., F, B., & A, G. (2017). Comparison of two insulin sensitizers, metformin and myo-inositol, in women with polycystic ovary syndrome (PCOS). Gynecological Endocrinology : The Official Journal of the International Society of Gynecological Endocrinology, 33(1), 39–42. https://doi.org/10.1080/09513590.2016.1236078
- Z, K., G, K., A, G., G, C., & AD, G. (2015). Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance. Gynecological Endocrinology : The Official Journal of the International Society of Gynecological Endocrinology, 31(2), 131–135. https://doi.org/10.3109/09513590.2014.964640
- AD, G., C, L., F, R., & VM, J. (2008). Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome. Gynecological Endocrinology : The Official Journal of the International Society of Gynecological Endocrinology, 24(3), 139–144. https://doi.org/10.1080/09513590801893232
- Yang, K., Zeng, L., Bao, T., & Ge, J. (2018). Effectiveness of Omega-3 fatty acid for polycystic ovary syndrome: a systematic review and meta-analysis. Reproductive Biology and Endocrinology : RB&E, 16(1). https://doi.org/10.1186/S12958-018-0346-X
- Sørensen, L. B., Søe, M., Halkier, K. H., Stigsby, B., & Astrup, A. (2012). Effects of increased dietary protein-to-carbohydrate ratios in women with polycystic ovary syndrome. The American Journal of Clinical Nutrition, 95(1), 39–48. https://doi.org/10.3945/AJCN.111.020693
- Mehrabani, H. H., Salehpour, S., Amiri, Z., Farahani, S. J., Meyer, B. J., & Tahbaz, F. (2013). Beneficial Effects of a High-Protein, Low-Glycemic-Load Hypocaloric Diet in Overweight and Obese Women with Polycystic Ovary Syndrome: A Randomized Controlled Intervention Study. Http://Dx.Doi.Org/10.1080/07315724.2012.10720017, 31(2), 117–125. https://doi.org/10.1080/07315724.2012.10720017
- Grantham, J. P., & Henneberg, M. (2014). The Estrogen Hypothesis of Obesity. PLOS ONE, 9(6), e99776. https://doi.org/10.1371/JOURNAL.PONE.0099776
- Lizcano, F., & Guzmán, G. (2014). Estrogen deficiency and the origin of obesity during menopause. BioMed Research International, 2014. https://doi.org/10.1155/2014/757461
- Greendale, G. A., Sternfeld, B., Huang, M., Han, W., Karvonen-Gutierrez, C., Ruppert, K., Cauley, J. A., Finkelstein, J. S., Jiang, S.-F., & Karlamangla, A. S. (2019). Changes in body composition and weight during the menopause transition. JCI Insight, 4(5). https://doi.org/10.1172/JCI.INSIGHT.124865
- Karvonen-Gutierrez, C., & Kim, C. (2016). Association of Mid-Life Changes in Body Size, Body Composition and Obesity Status with the Menopausal Transition. Healthcare, 4(3). https://doi.org/10.3390/HEALTHCARE4030042
- S, M., & BO, Y. (2019). Metabolic Syndrome During Menopause. Current Vascular Pharmacology, 17(6), 595–603. https://doi.org/10.2174/1570161116666180904094149
- Mauvais-Jarvis, F., Clegg, D. J., & Hevener, A. L. (2013). The Role of Estrogens in Control of Energy Balance and Glucose Homeostasis. Endocrine Reviews, 34(3), 309–338. https://doi.org/10.1210/ER.2012-1055